Completely rewritten and updated for its Fourth Edition, this best-selling text is a comprehensive, clear, concise, and easy-to-understand introduction to cardiovascular diseases. It is written by internationally recognized Harvard Medical School faculty and select medical students, and is the best text to bridge basic physiology with clinical care of patients. This edition provides updated coverage of pathogenesis of atherosclerosis, pathophysiology of acute coronary syndromes, mechanisms of heart failure, molecular mechanisms of dysrhythmias, the genomic basis of cardiomyopathies and congenital heart disease, and pharmacology. Numerous new illustrations are included. A companion Website on thePoint will include animations and audio heart sounds.